BIOB3200 Genetics and Molecular Diagnostics Course description

Det framgår av emneplanene om det er satt opp arbeidskrav eller obligatoriske aktiviteter innenfor et emne. Arbeidskrav og obligatoriske aktiviteter må være godkjent før studenten kan framstille seg til eksamen. Dersom arbeidskrav eller obligatoriske aktiviteter ikke er levert eller ikke er godkjent, mister studenten retten til å framstille seg til eksamen i det enkelte emne.

Vurdering og sensur foregår i samsvar med bestemmelsene om vurdering i lov av 8. mars 2024 nr. 9 om universiteter og høyskoler og forskrift om studier og eksamen ved OsloMet. Studentene plikter å sette seg inn i gjeldende regler. Det avholdes eksamen i hvert emne, og det benyttes ulike vurderingsformer. Det framgår av emneplanene hvilken vurderingsform, vurderingsuttryk, sensorordning og tilgjenglige hjelpemidler som benyttes for det enkelte emne.

After completing the course, the student is expected to have achieved the following learning outcomes defined in terms of knowledge, skills and general competence:

Knowledge

The student

• can describe the structure of the human genome and different types of inheritance
• can describe different forms of genetic variation and their significance
• can explain gene regulation
• can explain the significance of DNA damage, how it can occur and how it can be repaired
• is familiar with the use of tumor markers and other biomarkers in patient diagnostics and individually adapted medicine
• can describe the principles behind the most common analysis methods in molecular diagnostics and explaining the methods’ areas of use
• is familiar with different forms of non-invasive prenatal testing (NIPT)
• can describe how DNA analyses can be used for personal identification in forensic medicine
• can describe different sequencing technologies and their areas of use
• can explain how chromosome anomalies and hereditary diseases can be determined by using different methods
• is familiar with the laws and regulations that regulate genetic testing and the requirements relating to genetic counselling
• is familiar with methods and laws relating to sperm donation, egg donation and in vitro fertilisation

Skills

The student

• can conduct and quality assure different gene technology methods and assess any sources of errors related to these
• can apply analysis instruments used in molecular diagnostics
• can process data and interpret the results of different genetic/DNS analyses, both technical and biomedical
• can carry out bioinformatics analyses of sequencing data from different sequencing platforms
• can collect information from different databases and using basic bioinformatics tools
• can carry out work using gene technology methods in a responsible manner to minimise the risk of contamination

General competence

The student

• can discuss social and ethical consequences of gene testing in a medical perspective

Work and teaching methods include lectures, assignments, literature searches and laboratory work. The course entails a half-day’s practical training visit to an external laboratory.

Parts of the teaching used is the ‘flipped classroom’, where digital learning resources will be made available to students in advance and the time they spend at the university will be used to work on assignments and group work. Self-study, activity, reflection and cooperation is a pre-condition for completion of the course.

In order to be permitted to take the exam, the following must have been approved:

• a minimum of 90 per cent attendance in laboratory teaching
• laboratory reports in accordance with specified criteria

Supervised individual written exam, 4 hours

Alphanumeric/financial calculator with cleared memory. A digital calculator is available to the student during the exam.

A-F.

All answers are assessed by two examiners. An external examiner is used regularly, at a minimum of every third completion of the course. When selecting answers for external evaluation, a minimum of 10 percent of the answers shall be included, with no fewer than 5 answers. The external examiner’s assessment of the selected answers shall benefit all students.

10 credits overlap with BIO3200 Molecular Genetics